Nothing can stop the man with the right mental attitude from achieving his goal; nothing on earth can help the man with the wrong mental attitude.
The real sting here lies in Jefferson's symmetry: he's not simply saying optimism helps—he's claiming that attitude operates as a complete substitute for circumstance, which is both more radical and more humbling than the usual "believe in yourself" platitude. Notice he doesn't mention talent, resources, or luck, which means he's arguing that a wrong attitude can render even extraordinary advantages worthless. Consider the friend who inherited connections and capital yet sabotaged every opportunity through cynicism and blame-shifting, while another person with genuine disadvantages built something through sheer conviction—Jefferson would say the difference was never really about the external facts. The unsettling part is accepting that if this is true, we cannot credibly blame our setbacks on the world; we must look inward first.